“Fires were lit inside them”

LIT-PC3137-Oxygen therapy.indd

Lit Lunch 2/6/14

The putative eukaryotic translation initiation factor 5A (eIF5A) is a highly conserved and essential protein present in all organisms except bacteria. To be activated, eIF5A requires the conversion of a specific residue of lysine into hypusine. This hypusine modification occurs posttranslationally in two enzymatic steps, and the polyamine spermidine is the substrate. Despite having an essential...

Lit Lunch – December 6th

A major limitation of high-throughput DNA sequencing is the high rate of erroneous base calls produced. For instance, Illumina sequencing machines produce errors at a rate of ∼0.1–1 × 10 per base sequenced. These technologies typically produce billions of base calls per experiment, translating to millions of errors. We have developed a unique library preparation strategy, “circle sequencing,” w...

Conditions inside fisher dens during prescribed fires; what is the risk posed by spring underburns?

The use of spring prescribed fires to reduce accumulated fuel loads in western forests and facilitate the return of natural fire regimes is a controversial topic. While spring burns can be effective at reducing fuel loads and restoring heterogeneous landscapes, concerns exist over the potential impacts of unnaturallytimed fires to native species. To protect native wildlife from disturbance duri...

Lit Review – 9 - 20 - 16

Heat shock proteins (HSP) are expressed at high levels in cancer and form a fostering environment that is essential for tumor development. Here, we review the recent data in this area, concentrating mainly on Hsp27, Hsp70, and Hsp90. The overriding role of HSPs in cancer is to stabilize the active functions of overexpressed and mutated cancer genes. Thus, elevated HSPs are required for many of ...